Updated: Dustin Martin has been ruled out of Thursday night's clash against Brisbane.

Martin will miss the round 16 clash at the Gabba after experiencing "flu-like symptoms", the Tigers confirmed on Thursday afternoon.

Noah Cumberland comes in for the four-time All-Australian, with the Tigers' substitute to be named at 6.20pm AEST.

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Richmond will welcome Jacob Hopper back into its line-up for Thursday night's clash with Brisbane at the Gabba.

Hopper will be an exciting addition to the Tigers' midfield after the 26-year-old was sidelined for five games with a soleus injury.

Also returning to the team is midfielder Marlion Pickett, as was declared by the Club prior to Richmond's Round 14 St Kilda game and the bye. 

"Marlion's ready to play... He's a really tough, resilient person," senior coach Andrew McQualter said when speaking to the media on Wednesday at the Gabba.

The two inclusions replace Dion Prestia, who will miss with a calf strain, and omitted pair Maurice Rioli and Hugo Ralphsmith (last week's activated substitute). 

Ralphsmith has been named as an emergency, alongside Sam Banks, Noah Cumberland and Ivan Soldo. 

The Tigers will confirm which player steps into the 23 to be the substitute 60 minutes before the opening bounce.

McQualter said he was expecting a game of tough, contested footy.

"(Brisbane have) been great here for a long time, and a good team for a long time", he said.

"They've been really strong in the air the last few weeks as well, so that's something we're going to have to take care of tomorrow.

"A big challenge tomorrow night and we're looking forward to it."

Thursday night's clash at the Gabba kicks off at 7.20pm and will be broadcast live on Channel 7, Fox Footy and Kayo Sports.

Round 16, Richmond v Brisbane, Thursday, June 29, 7:20pm (AEST), Gabba (Swipe across on mobile)

In: Jacob Hopper, Marlion Pickett
Out: Dion Prestia (injured), Maurice Rioli (omitted), Hugo Ralphsmith (sub)