Richmond will look to rebound quickly after taking the fight to an inaccurate Melbourne outfit in the annual Anzac Day Eve clash at the MCG on Sunday night.
The Tigers fell to 2-4 to start their season after the 22-point loss to the Demons and have a trip to Perth to take on West Coast at Optus Stadium next Friday night.
Speaking after the loss to last year's premiers, coach Damien Hardwick said his group can still respond after an inconsistent start to its campaign.
"It's what we do – we pick up the pieces and we move on. There's some areas of our game we did well. There's some areas we need to improve. We get an opportunity every week. It's not like you're in the Olympics and you have to wait four years – we get an opportunity to get on the plane on Thursday and go over there and play some better footy," he said.
"What we've got to remember is we've played a really good side that will put a lot of sides to the sword this year. We got within 20 points, the scoreboard probably flattered us a little bit, but there's some signs that we're going OK in various areas."
Thomson Dow received a knock in the same area of his quad as he suffered last week, with the midfielder substituted out of the game in the second half and being ruled out of next week.